This paper focuses on the Patent commercialization and challenges faced by Universities in Tamil Nadu in commercializing a Patent. Though the awareness about Patent filings and the importance of the same is being known to the Universities, there still remain a lacuna in monetizing a Patent. This study aims to make a basic analysis of the underlining factors that hinder the process of Patent commercialization in the Universities in Tamil Nadu. These results are to understand the need for Patent Commercialization. The following factors are assessed and taken note of: Assessing the necessity, Identifying the actual requirements, Factors of challenges, and Leveraging hierarchical Structures. Without accessing these main elements, your role in successful commercialization won’t be successful.