This paper analyses how Employee well-being influences the working style of an organization in Industry 4.0. Manufacturing industries have experienced fast technical progress and development due to the Industry 4.0 revolution. Technological advancements allow for more efficient manufacturing processes while also bringing about changes in human work, which may pose new dangers to employee well-being and put existing skills and expertise to the test. Change resistance, the digital skills gap, employment hazards, expanding socio-economic inequities, a lack of industry-wide collaboration, leadership, and organizational culture difficulties are all revealed in the findings. Through socially responsible human resource practices, we show how HRM can be a critical enabler for long-term Industry 4.0 development. Sustainable Human Resource Practices, multi-stakeholder collaborations, holistic talent management, change leadership, inclusive knowledge sharing, education research, smart technology for upskilling and retention, and rewarding inclusive Industry 4.0 concepts are among them. Finally, we discuss potential research directions. Literature Review highlights the importance of providing information and opportunities for Employee well-being, in order to support Industry 4.0 transformations without impacting on workers’ motivation.